GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs9876781 | 1 | rs13314659 | chr3:48449149 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 10.57 | 6.51E-25 | Longevity |
| BRCA | cis | rs7637230 | 1 | rs13314673 | chr3:101661383 | LOC152225 | chr3:101659703-101716770:+ | -0.15 | -3.64 | 0.000287 | Psoriasis vulgaris;Psoriasis |
| BRCA | cis | rs9858542 | 1 | rs13316695 | chr3:49684917 | AMT | chr3:49454212-49460012:- | 0.11 | 3.57 | 0.000373 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs9858542 | 1 | rs13316695 | chr3:49684917 | GMPPB | chr3:49758932-49761384:- | -0.12 | -3.49 | 0.000499 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs10935120 | 1 | rs13322305 | chr3:134310791 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.59 | 5.21E-34 | Height |
| BRCA | cis | rs10935120 | 1 | rs13322305 | chr3:134310791 | CEP63 | chr3:134204575-134293852:+ | 0.14 | 3.81 | 0.000146 | Height |
| BRCA | cis | rs7647973 | 1 | rs13322887 | chr3:49555583 | AMT | chr3:49454212-49460012:- | -0.13 | -4.37 | 1.37E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13322887 | chr3:49555583 | CCDC36 | chr3:49235861-49295537:+ | -0.1 | -3.88 | 0.000111 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13322887 | chr3:49555583 | GMPPB | chr3:49758932-49761384:- | 0.13 | 3.8 | 0.000156 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13322887 | chr3:49555583 | NCKIPSD | chr3:48711280-48723334:- | -0.14 | -3.66 | 0.000268 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13322887 | chr3:49555583 | P4HTM | chr3:49027341-49044579:+ | -0.09 | -3.97 | 7.75E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs13322887 | chr3:49555583 | WDR6 | chr3:49044637-49053386:+ | 0.14 | 4.15 | 3.51E-5 | Menarche (age at onset) |
| BRCA | cis | rs9815354 | 1 | rs13325965 | chr3:41914942 | ULK4 | chr3:41288091-42003660:- | 0.51 | 14.02 | 4.1E-41 | Diastolic blood pressure |
| BRCA | cis | rs34286592 | 1 | rs13331733 | chr16:29848417 | LOC440356 | chr16:29875004-29879374:+ | -0.26 | -5.38 | 9.23E-8 | Multiple sclerosis |
| BRCA | cis | rs34286592 | 1 | rs13332078 | chr16:29850705 | LOC440356 | chr16:29875004-29879374:+ | -0.28 | -5.68 | 1.77E-8 | Multiple sclerosis |